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- Title
Detection of Epstein-Barr virus in epidermal skin lesions of an immunocompromised patient.
- Authors
Fermand, Jean-Paul; Gozlan, Joel; Bendelac, Albert; Delauche-Cavallier, Marie-Christine; Brouet, Jean-Claude; Morinet, Frederic; Fermand, J P; Gozlan, J; Bendelac, A; Delauche-Cavallier, M C; Brouet, J C; Morinet, F
- Abstract
Using in-situ hybridizaiton, we showed the presence of the Epstein-Barr (EB) virus genome in epidermal cells from a patient with chronic lymphocytic leukemia and unusual cutaneous lesions characterized clinically by a maculopapular eruption and histologically by epidermal cell degeneration and lymphoid cell infiltration. Such histologic changes are similar to those seen in graft-versus-host disease. The EB virus genome was mainly detected in the basal, germinative cells of the abnormal epithelium. Specimens of our patient's healthy skin were negative. The presence of EB virus DNA in skin lesions was confirmed by polymerase chain reaction adapted for analysis of paraffin-embedded tissue. These findings indicate that EB virus can infect the human epidermis and that the viral infection may produce a distinctive cutaneous disease.
- Subjects
EPSTEIN-Barr virus; LYMPHOCYTIC leukemia; IN situ hybridization; DNA analysis; CHRONIC lymphocytic leukemia; COMMUNICABLE diseases; HERPESVIRUS diseases; NUCLEIC acid hybridization; OPPORTUNISTIC infections; POLYMERASE chain reaction; SKIN diseases; DISEASE complications
- Publication
Annals of Internal Medicine, 1990, Vol 112, Issue 7, p511
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-112-7-511