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- Title
Drugs in development for herpes simplex and varicella zoster virus.
- Authors
Birkmann, A; Zimmermann, H
- Abstract
The alpha-herpesviruses varicella zoster virus (VZV) and herpes simplex virus (HSV) share common features including lifelong persistence in sensory ganglia and the risk of recurrences. For both HSV and VZV, standard-of-care (SoC) is based on nucleoside analogs (NAs), which require specific activation in infected cells. These existing drugs exhibit substantial limitations, warranting the development of new and more effective drugs.
- Subjects
VARICELLA-zoster virus diseases; HERPES simplex treatment; DRUG development; DISEASE relapse; SENSORY ganglia; PHYSIOLOGY; THERAPEUTICS
- Publication
Clinical Pharmacology & Therapeutics, 2017, Vol 102, Issue 1, p30
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1002/cpt.647