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- Title
A Study on the Correlation between the Severity of Parkinson's disease and Its Non-Motor Manifestations.
- Authors
Kundan; Kumar, Rajan; Kishore, Kaushal
- Abstract
Introduction: Parkinson's Disease has been known in India since ancient times. Parkinson's Disease is a progressive neurodegenerative disorder characterized by clinical features of bradykinesia, tremor and rigidity. Nearly all forms of PD results from a reduction of Dopaminergic transmission within the Basal ganglia. Aims: To study clinically around 50 patients of Idiopathic Parkinson's Disease having non-motor manifestations in and around Patna, Bihar, having a mixed population and the clinical correlation, if any, between non-motor symptoms with that of the severity of Parkinson's Disease in accordance with the stages 1 to 5 of the Modified Hoehn and Yahr Scale. Materials and method: This present study was Cross-sectional type of observational study. This study was conducted from April 2021 to October 2022of Patna Medical College and Hospital, Patna. Total 50 patients were included in this study. Result: Majority of the patients (58%), suffer from depression, followed by dementia (30%), followed by hallucination/illusion/delusion (24%), followed by panic attacks (18%). Percentage of depression was found to be highest in Stage 4 with 71.4% (5 out of 7), followed by Stage 5 (66.67%), Stage 2.5 (57.14%), stage 3 (54.54%), stage 2 stage 1.5 (40%) and stage 1 with (28.57%). The percentage of patients with RBD was highest in Stage 1.5 with 60% (3 out of 5), followed by Stage 3 (45.45), stage 5 (33.33%) and stage 2.5 (28.57%) followed by stage 1 (14.28%) and 4 (14.28%). The percentage of patients with RLS was highest in Stage 2 with 40% (4 out of 10), followed by Stage 5 with 33.3%. The percentage of patients with EDS was highest in Stage 1.5 with 100%, followed by Stage 5 with 66.7%. The percentage of patients with Nocturia was highest in Stage 5 with 100%, followed by Stage 3 with 72.7%. Conclusion: This study helps in screening patients with Parkinson's disease (PD) of non-motor symptoms (NMS) and aims at providing holistic treatment improving the quality of life. There is a need for large and well-designed prospective, adequately powered, large community-based study on the prevalence, the symptom, the efficacy of treatment, and the progression over time, of NMS in PD. This will provide a basis for improving the quality of care of these patients by clinicians.
- Subjects
PATNA (India); INDIA; PARKINSON'S disease; MOVEMENT disorders; NEUROLEPTIC malignant syndrome; PANIC attacks; BASAL ganglia
- Publication
European Journal of Cardiovascular Medicine, 2023, Vol 13, Issue 2, p1157
- ISSN
2042-4884
- Publication type
Article