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- Title
Expresión de metaloproteinasas en el proceso de palatogénesis: revisión sistemática de la literatura.
- Authors
Cuéllar Rivas, Estefanía; Ortiz Salazar, Mario Alejandro; Villavicencio Flórez, Judy
- Abstract
Background: Palate development is a complex event that requires the synthesis and degradation of various components of the extracellular matrix, such as collagen type I, II and III, fibronectin, and hyaluronic acid. Matrix metalloproteinases (MMPs) are a family of proteases responsible for tissue remodeling and its activity is regulated by their endogenous inhibitors (TIMPs). Several studies demonstrate the role of MMPs and TIMPs in palatogenesis and their relationship with cleft and lip palate. Purpose: To classify existing studies with experimental and human models that show the role of metalloproteinases and their inhibitors in palatal development and its relationship to diseases such as cleft lip and palate. Methods: This systematic literature was carried out in the PubMed, EMBASE, Web of Science, and Cochrane databases. The search included Boolean descriptors like palate, development, palatogenesis, matrix metalloproteinases (MMPs), tissue of metalloproteinases (TIMPs), extracellular matrix, and cleft lip and palate, in order to classify the studies related to the presence of MMPs and TIMPs in palate and the methods used to detect their expression between the years of 1997 and 2014. Results and Conclusion: Studies in animal models demonstrate the expression of MMP-2, MMP-3, MMP-9, MMP-13, MMP-25, ADAMTS9, ADAMTS20, and TIMPs in different stages of development in murine palate. By contrast, studies reported in humans are scarce and have been associated with polymorphisms of MMP-3 and MMP -25 associated with the presence of non-syndromic lip and cleft palate.
- Publication
Universitas Odontológica, 2014, Vol 33, Issue 71, p29
- ISSN
0120-4319
- Publication type
Article
- DOI
10.11144/Javeriana.uo33-71.empp