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- Title
Microvascular endothelial glycocalyx thickness is associated with brachial artery flow-mediated dilation.
- Authors
Smilowitz, Nathaniel R; Luttrell-Williams, Elliot; Golpanian, Michael; Engel, Alexis; Buyon, Jill P; Katz, Stuart D; Berger, Jeffrey S
- Abstract
In this observational study of 53 adults who underwent vascular function testing with sublingual SDF imaging and BART, we observed microvascular RBC filling and microvascular endothelial glycocalyx thickness were significantly associated with large-vessel endothelial function. Keywords: brachial artery reactivity; endothelial function; flow-mediated dilation; glycocalyx; microvascular EN brachial artery reactivity endothelial function flow-mediated dilation glycocalyx microvascular 563 565 3 10/08/21 20211001 NES 211001 Vascular endothelial dysfunction is an early manifestation of cardiovascular disease and is associated with incident cardiovascular events.[1] Brachial artery reactivity testing (BART) is used to noninvasively assess responsiveness to reactive hyperemia (flow-mediated dilation [FMD]) and evaluate nitric oxide [NO]-dependent large vessel endothelial function.[2][3]-[4] Although BART is the gold standard for the noninvasive evaluation of endothelial function, the technique requires substantial time and technical expertise for implementation.
- Subjects
ENDOTHELIUM diseases; BRACHIAL artery; GLYCOCALYX; CARDIOVASCULAR diseases; INSTITUTIONAL review boards; CORONARY artery disease
- Publication
Vascular Medicine, 2021, Vol 26, Issue 5, p563
- ISSN
1358-863X
- Publication type
Letter
- DOI
10.1177/1358863X211026765