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- Title
Should long-acting (depot) antipsychotics be used in early schizophrenia? A systematic review.
- Authors
Taylor, Mark; Ng, Ka Ying Bonnie
- Abstract
Background: The relapse rate after a first episode of schizophrenia is high, often due to non-adherence with medication. Long-acting injections of antipsychotics (LAI) are used to promote adherence to medication. Objective: To review the literature on the use of LAIs in first-episode and early schizophrenia. Method: A systematic electronic search of all original data containing peer-reviewed studies published in English using EMBASE, MEDLINE, Cochrane and PsychINFO from the onset of records. Reference lists from retrieved articles were examined for further relevant studies. Results: Ten studies were identified: two cohort studies; three randomised controlled trials; and five open studies. These studies, although limited, demonstrated the effectiveness of LAI in early schizophrenia. Seven of the 10 studies had risperidone long-acting injection as the only LAI. Conclusion: LAIs may be useful in the treatment of early schizophrenia in terms of symptom control and relapse reduction, particularly if chosen by the patient or when medication adherence is a priority. There is a need for a large-scale, randomised controlled trial comparing oral and LAI antipsychotics to assess long-term outcomes.
- Subjects
BRAIN physiology; DRUG therapy for schizophrenia; CONTROLLED release drugs; ANTIPSYCHOTIC agents; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDICAL information storage &; retrieval systems; PSYCHOLOGY information storage &; retrieval systems; MEDLINE; MOVEMENT disorders; ORAL drug administration; PATIENT compliance; PSYCHOLOGICAL tests; WEIGHT gain; SYSTEMATIC reviews; DISEASE remission; EARLY medical intervention; PATIENT readmissions
- Publication
Australian & New Zealand Journal of Psychiatry, 2013, Vol 47, Issue 7, p624
- ISSN
0004-8674
- Publication type
Article
- DOI
10.1177/0004867412470010