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- Title
Magnetosome mediated oral Insulin delivery and its possible use in diabetes management.
- Authors
Raguraman, Varalakshmi; Jayasri, M. A.; Suthindhiran, K.
- Abstract
Our study investigates the effect of magnetosome mediated oral Insulin delivery on diabetic induced rat models. The study involves the development of Magnetosome-Insulin (MI) conjugates by direct and indirect (by means of PEG) coupling method and further characterized by microscopic and spectroscopic analysis. The in vivo oral delivery of magnetosome-Insulin conjugate against streptozotocin-induced rat models and its efficiency was investigated. The impact of MI showed a remarkable change in the reduction of FBG levels up to 65% than the standard (Insulin). Similarly, the serum parameters: triglycerides (43.81%), AST&ALT (39.4 and 57.2%), total cholesterol (43.8%) showed significant changes compared to the diabetic control. The histological results of MI treated rats were found similar to control rats. Thus, these significantly notable results on diabetic rats depicts that magnetosomes can be employed as a potential approach and a very promising alternative for the parenteral route of Insulin delivery.
- Subjects
STREPTOZOTOCIN; INSULIN; GLYCEMIC control; MICROSCOPY; DIABETES; MAGNETOSOMES
- Publication
Journal of Materials Science: Materials in Medicine, 2020, Vol 31, Issue 8, pN.PAG
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-020-06417-2