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- Title
CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1<sup>+</sup> viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion.
- Authors
Correa-Rocha, Rafael; Lopez-Abente, Jacobo; Gutierrez, Carolina; Pérez-Fernández, Verónica Astrid; Prieto-Sánchez, Adrián; Moreno-Guillen, Santiago; Muñoz-Fernández, María-Ángeles; Pion, Marjorie
- Abstract
In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an immunosuppressive state via limitation of the HIV-1-specific T-cell responses. CD100 was demonstrated to play a relevant role in immune responses in various pathological processes and may be responsible for immune dysregulation during HIV-1 infection. We investigated the function of CD72/CD100, and PD-1/PDL-1 axes on T and B cells in HIV-infected individuals and in healthy individuals. We analyzed the frequencies and fluorescence intensities of these four markers on CD4+, CD8+ T and B cells. Marker expressions were increased during active HIV-1 infection. CD100 frequency on T cells was positively associated with the expression of PD-1 and PD-L1 on T cells from HIV-infected treatment-naïve individuals. In addition, the frequency of CD72-expressing T cells was associated with interferon gamma (IFN-γ) production in HIV-infected treatment-naïve individuals. Our data suggest that the CD72/CD100 and PD-1/PD-L1 axes may jointly participate in dysregulation of immunity during HIV-1 infection and could partially explain the immune systems’ hyper-activation and exhaustion.
- Subjects
PROGRAMMED cell death 1 receptors; T cells; IMMUNE response; PUBLIC health; STATISTICAL correlation; PHYSIOLOGY
- Publication
PLoS ONE, 2018, Vol 13, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0203419