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- Title
Prognostic value of novel neutrophil-to-hemoglobin and lymphocyte score in patients with acute myocardial infarction.
- Authors
Kim, Hyeon Jeong; Lee, Jang Hoon; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Jeong, Myung H; Park, Jong-Seon; Kim, Hyo-Soo; Hur, Seung-Ho; Seong, In-Whan; Cho, Myeong-Chan; Chae, Shung Chull
- Abstract
We developed and assessed whether a novel neutrophil-to-hemoglobin and lymphocyte (NHL) score would improve the ability to predict clinical outcome compared with neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) in acute myocardial infarction (AMI). We examined 13,072 AMI patients from the Korean AMI Registry–National Institute of Health database. NHL score was calculated as follows: NHL score (U) = N/(Hb × L), where N, Hb, and L are baseline blood neutrophil, hemoglobin, and lymphocyte count. The primary outcome was the occurrence of major adverse cerebrocardiovascular events (MACCEs) at 2 years. The NLR, SII, and NHL score were independent predictors of 2-year MACCEs. The area under the curve of the NHL score (0.637) for predicting 2-year MACCEs was significantly higher compared with those of SII (0.589) and NLR (0.607). The NHL score significantly improved the reclassification and integrated discrimination compared with NLR (p < 0.0001) and SII (p < 0.0001). A high NHL score (≥ 0.35 U) was an independent predictor of 2-year MACCEs (adjusted hazard ratio, 1.41; 95% confidence interval, 1.29–1.55; p < 0.001). The NHL score could be a novel model for predicting long-term MACCEs in patients with AMI.
- Subjects
MYOCARDIAL infarction; PROGNOSIS; LYMPHOCYTES; NEUTROPHIL lymphocyte ratio; LYMPHOCYTE count
- Publication
European Journal of Inflammation, 2021, p1
- ISSN
1721-727X
- Publication type
Article
- DOI
10.1177/20587392211039095