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- Title
Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3 in Relation to Hemoglobin Concentration in Healthy Term Infants.
- Authors
Koç, Esin; Bideci, Aysun; Cinaz, Peyami; Unlu, Mustafa; Atalay, Yildiz; Türkyilmaz, Canan
- Abstract
In order to evaluate the role of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) in the maintenance of blood Hb concentration in infants, we studied the serum concentrations of IGF-I and IGFBP-3 in relation to blood hemoglobin values in 25 healthy term infants at birth and two months of age. The mean concentration of IGF-I was 18.6±7.1 ng/ml and IGFBP-3 was 1240±498 ng/ml at birth. Positive correlation was observed between the blood Hb concentrations and both IGF-I (r=0.56, p=0.004) and IGFBP-3 levels (r=0.38, p=0.04) at the first examination. Our results show that blood Hb is positively correlated to serum IGF-I levels indicating indirectly the involvement of mediators of growth hormone in the regulation of physiologic Hb concentrations at birth. As no relationship was found between IGF-I, IGFBP-3 and Hb levels at the second examination, the same association could not be demonstrated at two months of age.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 1997, Vol 10, Issue 6, p609
- ISSN
0334-018X
- Publication type
Article