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- Title
An Efficient Stereoselective Total Synthesis of All Stereoisomers of the Antibiotic Thiamphenicol through Ruthenium-Catalyzed Asymmetric Reduction by Dynamic Kinetic Resolution (Eur. J. Org. Chem. 27/2015).
- Authors
Perez, Marc; Echeverria, Pierre‐Georges; Martinez‐Arripe, Elsa; Ez Zoubir, Mehdi; Touati, Ridha; Zhang, Zhaoguo; Genet, Jean‐Pierre; Phansavath, Phannarath; Ayad, Tahar; Ratovelomanana‐Vidal, Virginie
- Abstract
The cover picture shows how chemists, by the judicious choice of the catalytic system, can control the stereochemical outcome of the ruthenium‐catalyzed enantioselective reduction of an inexpensive and readily available racemic α‐amido‐β‐keto ester derivative. More particularly, a dynamic kinetic resolution (DKR) process, through either asymmetric hydrogenation (AH) or asymmetric transfer hydrogenation (ATH), allowed the formation of the essential syn or anti relationship of key amino alcohols leading to the synthesis of all four stereoisomers of the antibiotic thiamphenicol. Details are discussed in the article by T. Ayad, V. Ratovelomanana‐Vidal et al. on 5949 ff.
- Subjects
ORGANIC chemistry; CHEMISTRY periodicals; MAGAZINE covers
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 27, pn/a
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201590076