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- Title
Effects of ketamine on penile tissues in an experimental priapism model in rats.
- Authors
Kölükçü, Vildan; Balta, Mehtap Gürler; Tapar, Hakan; Karaman, Tugba; Karaman, Serkan; Unsal, Velid; Gevrek, Fikret; Yalçın, Kenan; Fırat, Fatih
- Abstract
BACKGROUND: This study aimed to evaluate the histopathological and biochemical effects of ketamine on penile tissues following ischemia-reperfusion injury induced by priapism. METHODS: Twenty-four male rats were randomized into three groups. Group 1 served as the control group. Group 2 underwent the priapism model to induce ischemia-reperfusion injury. Group 3, the treatment group, experienced a similar ischemia-reperfusion model as Group 2; additionally, 50 mg/kg of ketamine was administered intraperitoneally just before reperfusion. Blood biochemical analyses and penile histopathological evaluations were performed. RESULTS: In Group 3, significant improvements were observed in all histopathological scores, including desquamation, edema, inflammation, and vasocongestion compared to Group 2 (p<0.001). Blood biochemical analyses showed that the malondialdehyde (MDA) levels were recorded as 10 in Group 2, with a significant decrease in Group 3 (p=0.013). Similarly, proinflammatory cytokine levels, including interleukin-1 beta (IL-1ß), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-a), were found to be suppressed in Group 3 compared to Group 2 (p=0.003, p=0.022, and p=0.028, respectively). Antioxidant enzyme activities, such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.016 and p=0.024, respectively). CONCLUSION: Ketamine is an effective anesthetic agent in alleviating the effects of penile ischemia-reperfusion injury.
- Subjects
BIOLOGICAL models; SUPEROXIDE dismutase; REPERFUSION injury; KETAMINE; INTRAPERITONEAL injections; BLOOD chemical analysis; PRIAPISM; TREATMENT effectiveness; DESCRIPTIVE statistics; RATS; EXPERIMENTAL design; PENIS; ANIMAL experimentation; HISTOLOGICAL techniques; ANTIOXIDANTS; COMPARATIVE studies; INFLAMMATION; CYTOKINES; GLUTATHIONE peroxidase; MALONDIALDEHYDE; INTERLEUKINS; TUMOR necrosis factors; PHARMACODYNAMICS; DISEASE complications
- Publication
Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi, 2024, Vol 30, Issue 5, p309
- ISSN
1306-696X
- Publication type
Article
- DOI
10.14744/tjtes.2024.33262