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- Title
Factors Associated with Poor Clinical Outcome after Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) for Acute Ischemic Stroke in Northeastern Thailand.
- Authors
N., Vorasoot; J., Sothornwit; A., Chomjit; N., Kasemsap; S., Tiamkao; K., Sawanyawisuth; K., Kongbunkiat
- Abstract
Objective: To evaluate the factors associated with poor treatment outcomes of acute ischemic stroke after intravenous recombinant tissue plasminogen activator (rt-PA) therapy from 7 hospitals in Northeastern Thailand. Materials and Methods: The present study was a retrospective analytical study. Data were obtained from medical records of acute ischemic stroke patients who reached hospital within 4.5 hours after onset and received rt-PA during 2008 May to 2012 April. The authors evaluated time and process to access hospital, duration of treatment process, and factor associated with good and poor clinical outcomes. Results: During the study period, 778 patients met the study criteria. Mean onset-to-door time was 1.85+1.05 hours. Previous visiting medical center unavailable for rt-PA made patients delay reaching hospitals (OR 1.62 (95% CI 1.28 to 2.04), p-value <0.001). Mean onset-to-needle time was 3.08+1.11 hours. Factors leading to poor outcome were atrial fibrillation (AF) (OR 2.38 (95% CI 1.33 to 4.23), p-value = 0.003) and onset-to-needle time more than 180 minutes (OR 14.78 (95% CI 7.91 to 27.62), p-value <0.001). Conclusion: Patients came to hospital late because of previously visiting medical centers where rt-PA-was unavailable. Atrial fibrillation and onset-to-needle time more than 180 minutes associated to poor outcome.
- Subjects
THAILAND; TISSUE plasminogen activator; ATRIAL fibrillation; STROKE; MEDICAL centers
- Publication
Journal of the Medical Association of Thailand, 2020, Vol 103, p81
- ISSN
0125-2208
- Publication type
Article