We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ultrasound Shear Wave Elastography for Evaluation of Diaphragm Stiffness in Patients with Stable COPD: A Pilot Trial.
- Authors
Xu, Jing‐Hong; Wu, Zhen‐Zhou; Tao, Fang‐Yi; Zhu, Shu‐Ting; Chen, Shun‐Ping; Cai, Chang; Liang, Zeng‐Hui; Shi, Bin‐Bin; Chen, Bin; Xie, Yu‐Peng
- Abstract
Objectives: Skeletal muscle dysfunction is one of the most common comorbidities in chronic obstructive pulmonary disease (COPD). The occurrence of respiratory failure in COPD is common and leads to the patient's death. The diaphragm is the most important muscle in the respiratory system and plays a key role in the onset of respiratory failure. This study explores the feasibility of ultrasound shear wave elastography (SWE) to measure diaphragmatic stiffness and evaluates its changes in COPD patients. Methods: In total, 77 participants (43 patients with stable COPD and 34 healthy controls) were enrolled. All subjects underwent complete diaphragmatic ultrasound SWE measurements and pulmonary function tests. The diaphragmatic stiffness was indicated via diaphragmatic shear wave velocity (SWV) at functional residual capacity (FRC). A trained operator performed the ultrasound SWE examinations of the first 15 healthy controls thrice to assess the reliability of diaphragmatic SWE. Results: A good to excellent reliability was found in diaphragmatic SWV at FRC (ICC = 0.93, 95%CI 0.82–0.98). As compared to the control group, the diaphragmatic SWV at FRC was considerably high in the COPD group (median 2.5 m/s versus 2.1 m/s, P =.008). Diaphragmatic SWV at FRC was linked to forced expiratory volume in one second (r = −0.30, P =.009), forced vital capacity (r = −0.33, P =.003), modified Medical Research Council score (r = 0.30, P =.001), and COPD assessment test score (r = 0.48, P <.001). Conclusions: Ultrasound SWE may be employed as an effective tool for quantitative evaluation of diaphragm stiffness and can help in personalized management of COPD, such as treatment guidance and follow‐up monitoring.
- Subjects
CHRONIC obstructive pulmonary disease; SHEAR waves; ULTRASONIC imaging; DIAPHRAGM (Anatomy); FORCED expiratory volume; PULMONARY function tests; RESPIRATORY muscles; SKELETAL muscle; MEDICAL Research Council (Great Britain)
- Publication
Journal of Ultrasound in Medicine, 2021, Vol 40, Issue 12, p2655
- ISSN
0278-4297
- Publication type
Article
- DOI
10.1002/jum.15655