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- Title
Transmission of low-density hepatitis C viral particles during sexually transmitted acute resolving infection.
- Authors
Diaz, Olivier; Cubero, Maria; Trabaud, Mary Anne; Quer, Josep; Icard, Vinca; Esteban, Juan I.; Lotteau, Vincent; André, Patrice
- Abstract
Hepatitis C viruses in the blood of chronically infected patients are heterogeneous in density with the presence of lipoprotein associated viral particles of lower density than conventional virions. If low-density viral particles have been shown to be infectious in animal models it is currently not known whether these particles display the same infectivity for humans. In a case of sexually transmitted acute resolving infection, all isolated NS3 sequences from the acute-phase isolate clustered with a single sequence from the chronic carrier isolate, suggesting bottlenecking during transmission. To determine the density of the transmitted viruses, viral quasispecies from fractions with density below and above 1.055 g/ml were isolated and prepared from the plasma of the chronically infected sexual partner. Interestingly, the three closest sequences to the recipient consensus sequence were isolated from the low-density fraction. These data suggest that low-density viral particles are infectious for humans as they are for chimpanzees and that they can be transmitted during sexual intercourse. J. Med. Virol. 80:242-246, 2008. © 2007 Wiley-Liss, Inc.
- Publication
Journal of Medical Virology, 2008, Vol 80, Issue 2, p242
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.21037