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- Title
Efficacy evaluation of pepsin in laparoscopic antireflux surgery for gastroesophageal reflux disease.
- Authors
Gao, Xiang; Liu, Dian-Gang; Wang, Feng; Zhang, Chao; Du, Xing; Wu, Ji-Min; Wang, Zhong-Gao; Li, Fei
- Abstract
<bold>Background: </bold>The false positive rate of the PPI test for the diagnosis of typical symptoms of gastroesophageal reflux disease (GERD) is extremely high.<bold>Objective: </bold>This study aims to investigate the effect of the pepsin test on GERD and laparoscopy-assisted anti-reflux surgery for GERD.<bold>Methods: </bold>A total of 30 GERD patients were enrolled into this study, and the pre-diagnosis of GERD was determined by symptom evaluation, impedance-pH examination, gastroscopy and pepsin test. All patients underwent surgery.<bold>Results: </bold>Among the 30 GERD patients, 18 patients were male and 12 were female, and their average age was 58.2 + 12.6 years old. The patients were treated with laparoscopic fundoplication and hiatus hernia repair after preoperative assessment. A total of 28 patients were followed up, one patient developed recurrent symptoms, and one patient developed postoperative dysphagia and received non-operative treatment. Furthermore, the symptom scores were significantly lower at postoperative pepsin detection when compared to the scores before the operation (pepsin: preoperative: 148.8 ± 82.6, postoperative: 30.7 ± 24.6; t= 4.848, P= 0.000).<bold>Conclusions: </bold>Laparoscopic fundoplication and hiatus hernia repair may effectively control the symptoms of GERD. Furthermore, the detection of pepsin is non-invasive and easy to operate.
- Subjects
PEPSIN; GASTROESOPHAGEAL reflux; LAPAROSCOPIC surgery; GASTROSCOPY; FUNDOPLICATION; GASTROESOPHAGEAL reflux diagnosis; TREATMENT effectiveness; LAPAROSCOPY
- Publication
Technology & Health Care, 2021, Vol 29, Issue 1, p91
- ISSN
0928-7329
- Publication type
journal article
- DOI
10.3233/THC-192090