We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dermal infiltrates of cutaneous T-cell lymphomas with epidermotropism but not other cutaneous lymphomas are abundant with langerin<sup>+</sup> dendritic cells.
- Authors
Der-Petrossian, M.; Valencak, J.; Jonak, C.; Klosner, G.; Dani, T.; Müllauer, L.; Pehamberger, H.; Knobler, R.; Trautinger, F.
- Abstract
Background The Langerhans cell (LC) hypothesis suggests that cutaneous T-cell lymphomas (CTCL) are diseases of chronic T-cell stimulation by LC-mediated antigen presentation. Objective To investigate a broad panel of CTCL and cutaneous B-cell lymphomas (CBCL) for the spatial association of langerin+ dendritic cells (DC) with T and B cells in the skin, respectively. Methods Fifty-five specimens of CTCL and 10 of CBCL were double-stained with monoclonal antibodies against langerin and CD3 or CD20, respectively, and evaluated by confocal laser scan microscopy. Results Dermal infiltrates in mycosis fungoides (n = 38), primary cutaneous CD4+ small ⁄ medium-sized pleomorphic T-cell lymphoma (n = 3) and primary cutaneous peripheral T-cell lymphoma, unspecified (n = 3) were characterized by a high frequency of dermal langerin+ DCs. These cells were exclusively present in the malignant infiltrates. No direct co-localization of CD3 and langerin could be resolved. Dermal langerin+ cells were detected only in one of six primary cutaneous anaplastic large cell lymphomas (C-ALCL), characterized by epidermotropism. In other C-ALCL cases (five of six), in lymphomatoid papulosis (n = 3), subcutaneous panniculitis-like T-cell lymphoma (n = 2), and all variants of CBCL no dermal langerin+ DCs could be found. Conclusions Langerin+ DCs are abundant in the dermal infiltrates of T-cell lymphomas with specific involvement of the epidermis. This might indicate that immature LC and neoplastic T cells interact and gives rise to further studies to characterize the phenotype of the langerin+ cell population described here and its role in the pathology of CTCL.
- Subjects
LANGERHANS cells; CONFOCAL microscopy; MYCOSIS fungoides; T-cell lymphoma; DENDRITIC cells; EPIDERMIS; PHYSIOLOGY
- Publication
Journal of the European Academy of Dermatology & Venereology, 2011, Vol 25, Issue 8, p922
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2010.03882.x