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- Title
Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK
- Authors
Wang, Ming; Li, Chenglong; Nie, Hui; Lv, Xin; Qu, Ying; Yu, Beiqin; Su, Liping; Li, Jianfang; Chen, Xuehua; Ju, Jingfang; Yu, Yingyan; Yan, Min; Gu, Qinlong; Zhu, Zhenggang; Liu, Bingya
- Abstract
Abstract: Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis.
- Subjects
GENETIC regulation; METASTASIS; STOMACH cancer; GENE targeting; TUMOR growth; GENE expression
- Publication
FEBS Letters, 2012, Vol 586, Issue 16, p2382
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.05.050