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- Title
Dosimetric comparison of helical tomotherapy, VMAT, fixed-field IMRT and 3D-conformal radiotherapy for stage I-II nasal natural killer T-cell lymphoma.
- Authors
Xianfeng Liu; Erliang Huang; Ying Wang; Yanan He; Huanli Luo; Mingsong Zhong; Da Qiu; Chao Li; Han Yang; Guanglei He; Juan Zhou; Fu Jin; Liu, Xianfeng; Huang, Erliang; Wang, Ying; He, Yanan; Luo, Huanli; Zhong, Mingsong; Qiu, Da; Li, Chao
- Abstract
<bold>Background: </bold>The aim of this study was to compare radiotherapy plans for Stage I-II nasal natural killer/T-cell lymphoma (NNKTL) using helical tomotherapy (HT), volumetric-modulated arc therapy (VMAT), Fixed-Field intensity-modulated radiotherapy (IMRT), and three-dimensional conformal radiotherapy (3D-CRT).<bold>Methods: </bold>Eight patents with Stage I-II NNKTL treated with IMRT were re-planned for HT, VMAT (two full arcs), and 3D-CRT. The quality of target coverage, the exposure of normal tissue and the efficiency of radiation delivery were analyzed.<bold>Results: </bold>HT showed significant improvement over IMRT in terms of D98%, cold spot volume and homogeneity index (HI) of planning target volume (PTV). VMAT provided best dose uniformity (p = 0.000) to PTV, while HT had best dose homogeneity among the four radiotherapy techniques (p = 0.000) to PTV. VMAT obviously reduced treatment time (p = 0.010; 0.000) compared to HT and IMRT. Mean dose of left and right optic nerve was significantly reduced by IMRT compared to HT (19.86%, p = 0.000; 21.40%, p = 0.002) and VMAT (8.97%, p = 0.002; 9.35%, p = 0.001), and maximum dose of left lens of VMAT increased over the HT (36.25%, p = 0.043) and IMRT (40.65%, p = 0.001).<bold>Conclusion: </bold>The unexpected results show that both HT and VMAT can achieve higher conformal treatment plans while getting worse organs at risk (OARs) sparing than IMRT for patients with Stage I-II NNKTL. VMAT requires the shortest delivery time, and IMRT delivers the lowest dose to most OARs. The results could provide guidance for selecting proper radiation technologies for different cases.
- Subjects
T-cell lymphoma; RADIOTHERAPY; RADIATION dosimetry; ONCOLOGY; VOLUME (Cubic content); THERAPEUTICS; HUMAN body; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; NASAL tumors; RADIATION doses; RESEARCH; TUMOR classification; THREE-dimensional imaging; EVALUATION research
- Publication
Radiation Oncology, 2017, Vol 12, p1
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-017-0812-1