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- Title
Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells.
- Authors
Miharada, Kenichi; Hiroyama, Takashi; Sudo, Kazuhiro; Nagasawa, Toshiro; Nakamura, Yukio
- Abstract
Erythroblast enucleation is thought to be largely dependent on signals mediated by other cells, such as macrophages. In an attempt to improve the in vitro production of red blood cells (RBCs) from immature hematopoietic progenitor cells, we have developed a method to produce enucleated RBCs efficiently in the absence of feeder cells. Our method may represent an efficient way to produce transfusable RBCs on a large scale from hematopoietic progenitors.
- Subjects
ERYTHROCYTES; CELL enucleation; BLOOD cells; HEMATOPOIETIC stem cells; KILLER cells; MACROPHAGES; CELL nuclei; CYTOLOGICAL techniques
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 10, p1255
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1245