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- Title
Toward a universal multistrain bacterial vaccine.
- Authors
Feldman, Robert G.
- Abstract
The article presents an approach using multi-strain genome analysis to identify a multicomponent protein-containing vaccine that could be used as the basis for a group B Streptococcus (GBS) vaccine with near-universal coverage. GBS can be killed in the presence of complement-fixing antibody, complement and macrophages. In the absence of any vaccine, many countries advocate a policy in which women who are shown to be GBS carriers late in pregnancy are offered intravenous antibiotics throughout labor. However, although the technical hurdles for preventing GBS infections seem to have been overcome, substantial regulatory and legal challenges remain before any GBS vaccine could become commercially available.
- Subjects
BACTERIAL vaccines; GENOMICS; PREVENTIVE medicine; STREPTOCOCCUS; MACROPHAGES; ANTI-infective agents
- Publication
Nature Biotechnology, 2005, Vol 23, Issue 9, p1087
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0905-1087