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- Title
Submandibular gland transfer for the prevention of radiation‐induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era.
- Authors
Kutuk, Tugce; McAllister, Nicole C.; Rzepczynski, Amy E.; Williams, Andre; Young, Geoffrey; Crawley, Meghan B.; Rabinowits, Guilherme; Kaiser, Adeel; Contreras, Jessika A.; Kalman, Noah S.
- Abstract
Background: Submandibular gland (SMG) transfer decreased radiation‐associated xerostomia in the 2/3‐dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans. Methods: Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated. Mean salivary gland, oral cavity, and larynx doses were compared between clinical plans and reoptimized plans. Results: No statistically significant difference in mean SMG dose (27.53 Gy vs. 29.61 Gy) or total salivary gland dose (26.12 Gy vs. 26.41 Gy) was observed with or without SMG transfer (all p > 0.05). Mean oral cavity and larynx doses were not statistically different. Neither tumor site, target volume crossing midline, stage, nor salivary gland volumes were associated with mean doses. Conclusions: Salivary gland doses were similar with or without SMG transfer. IMRT likely decreases the benefit of SMG transfer on the risk of radiation‐associated xerostomia.
- Subjects
SUBMANDIBULAR gland; INTENSITY modulated radiotherapy; OROPHARYNGEAL cancer; XEROSTOMIA; RADIATION dosimetry
- Publication
Head & Neck, 2022, Vol 44, Issue 5, p1213
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27021