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- Title
Local radiotherapy versus nonradiotherapy to distant lesions for metastatic nasopharyngeal carcinoma: Retrospective cohort study.
- Authors
Yang, Lianlian; Xue, Yinyin; Wei, Zhigong; Ren, Kexing; Liu, Zheran; Chang, Tangel; Peng, Xingchen; Su, Yonglin; Li, Yan
- Abstract
Background: To evaluate the efficiency of local radiotherapy to metastatic lesions in patients with metastatic nasopharyngeal carcinoma (mNPC). Methods: The overall survival was observed and compared for mNPC patients who received local radiotherapy versus nonradiotherapy to metastatic lesions by using the Kaplan–Meier method and Cox analysis. Results: One hundred and nine patients with NPC were involved in this study, with 61 (56.0%) received radiotherapy to metastatic sites and 48 (44.0%) did not receive radiotherapy to metastatic sites. The 2‐ and 5‐year OS for patients who received local radiotherapy to metastatic lesions were 65.8% and 35.7%, and for patients who did not receive radiotherapy to metastatic lesions were 45.3% and 26.2%. The multivariable adjusted hazard radios for local radiotherapy versus nonradiotherapy to metastatic lesions were 0.482 (95% confidence interval is 0.278–0.834, p = 0.009). Conclusions: Local radiotherapy to metastatic lesions might be a protective factor for patients with mNPC.
- Subjects
NASOPHARYNX cancer; METASTASIS; RADIOTHERAPY; COHORT analysis; OVERALL survival
- Publication
Head & Neck, 2022, Vol 44, Issue 3, p615
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26953