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- Title
Modulation of protein biophysical properties by chemical glycosylation: biochemical insights and biomedical implications.
- Authors
Solá, R. J.; Rodríguez-Martínez, J. A.; Griebenow, K.
- Abstract
Glycosylation constitutes one of the most important posttranslational modifications employed by biological systems to modulate protein biophysical properties. Due to the direct biochemical and biomedical implications of achieving control over protein stability and function by chemical means, there has been great interest in recent years towards the development of chemical strategies for protein glycosylation. Since current knowledge about glycoprotein biophysics has been mainly derived from the study of naturally glycosylated proteins, chemical glycosylation provides novel insights into its mechanistic understanding by affording control over glycosylation parameters. This review presents a survey of the effects that natural and chemical glycosylation have on the fundamental biophysical properties of proteins (structure, dynamics, stability, and function). This is complemented by a mechanistic discussion of how glycans achieve such effects and discussion of the implications of employing chemical glycosylation as a tool to exert control over protein biophysical properties within biochemical and biomedical applications.
- Subjects
GLYCOSYLATION; BIOPHYSICS; PROTEOLYTIC enzymes; PROTEINS; ESTERIFICATION
- Publication
Cellular & Molecular Life Sciences, 2007, Vol 64, Issue 16, p2133
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-007-6551-y