We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Snake venom thrombin-like enzymes: from reptilase to now.
- Authors
Castro, H. C.; Zingali, R. B.; Albuquerque, M. G.; Pujol-Luz, M.; Rodrigues, C. R.
- Abstract
The snake venom thrombin-like enzymes (SVTLEs) comprise a number of serine proteases functionally and structurally related to thrombin. Until recently, only nine complete sequences of this subgroup of the serine protease family were known. Over the past 5 years, the primary structure of several SVTLEs has been characterized, and now this family includes several members. Of particular interest is their possible use in pathologies such as thrombosis. The aim of the present review is to summarize the state of the art concerning the evolutionary, structural and biological features of the SVTLEs.
- Subjects
SNAKE venom; ENZYMES; FIBRINOGEN; BLOOD platelets; SERINE proteinases
- Publication
Cellular & Molecular Life Sciences, 2004, Vol 61, Issue 7/8, p843
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-003-3325-z