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- Title
EVALUATION OF NEW SCLEROTIC BONE METASTASES IN BREAST CANCER PATIENTS DURING TREATMENT.
- Authors
Çiray, I.; Åström, G.; Andréasson, I.; Edekling, T.; Hansen, J.; Bergh, J.; Ahlström, H.
- Abstract
AbstractPurpose: According to the World Health Organization (WHO) criteria for response of bone metastases to therapy, new lesions indicate progressive disease. We intended to prove that a new sclerotic lesion on conventional radiography may also be a sign of a positive therapeutic response in a previously undetectable lytic metastasis. Material and Methods: In a previous placebo-controlled clinical trial of clodronate (Ostac) therapy, 139 breast cancer patients with bone metastases underwent both conventional radiography and bone scan every 6 months for 2 years with 99mTc before and during clodronate treatment. WHO criteria were applied for therapy response evaluation. Results: In 24 patients, 52 new sclerotic lesions observed during therapy were selected for re-evaluation of conventional radiographs and bone scans. In 8 of the 24 patients, 17 of 52 new sclerotic lesions (33%) had showed positive uptake on previous bone scans. These lesions were possibly misinterpreted as new when applying WHO criteria. Conclusion: For better assessment of new sclerotic lesions during treatment, more sensitive techniques, e.g. bone scan, are needed as a complement to conventional radiography.
- Subjects
BONE metastasis; BREAST cancer; DIAGNOSIS
- Publication
Acta Radiologica, 2000, Vol 41, Issue 2, p178
- ISSN
0284-1851
- Publication type
Article
- DOI
10.1034/j.1600-0455.2000.041002178.x