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- Title
Exploding more myths about adrenaline.
- Authors
Roberts, Graham; Alviani, Cherry; Angier, Elizabeth
- Abstract
However, we cannot extrapolate to say that an EpiPen 0.5 mg would also be better than an EpiPen 0.3 mg device as the former is likely to deliver even higher first-peak plasma adrenaline levels which may depress cardiac output further impairing its effectiveness. In other cases, a high plasma adrenaline level is associated with reduced cardiac output[4] or even Takotsubo syndrome.[6] The data presented by Patel et al. illustrates how different adrenaline autoinjectors give very different plasma adrenaline profiles making it difficult to extrapolate from one device to another. However, at high concentrations of adrenaline, the beta-2-adrenergic receptor activates an inhibitory G-protein.[5] This is thought to be the mechanism underlying Takotsubo cardiomyopathy which has been associated with high doses of adrenaline.[6] In this condition, transient cardiac dysfunction is seen.
- Subjects
ADRENALINE; TAKOTSUBO cardiomyopathy; YOUNG adults; MYTH; EPINEPHRINE autoinjectors; BETA adrenoceptors
- Publication
Allergy, 2023, Vol 78, Issue 7, p1740
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15767