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- Title
Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non‐steroidal anti‐inflammatory drug exacerbated respiratory disease.
- Authors
Andiappan, Anand Kumar; Asad, Mohammad; Chua, Celine; Sehanobish, Esha; Ren, Zhen; Chan, Xue Ying; Lum, Josephine; Ang, Nicholas; Duan, Kaibo; Gersten, Adam; Abuzeid, Waleed M.; Akbar, Nadeem; Gibber, Marc; Howland, Shanshan; Lee, Bernett; Rotzschke, Olaf; Porcelli, Steven A.; Jerschow, Elina
- Abstract
Conversely, tissue neutrophil association with LM scores in N-ERD patients suggests that neutrophils contribute to the severity of the polyp burden in N-ERD. Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non-steroidal anti-inflammatory drug exacerbated respiratory disease Neutrophil counts were higher in the nasal polyp tissues of N-ERD patients (8.5 cells per hpf (IQR 3-25) vs. 2.5 cells (IQR 2-5) in non-N-ERD ( I p i = .026, Figure 1B).
- Subjects
NASAL polyps; RESPIRATORY diseases; ANTI-inflammatory agents; RESPIRATORY agents; INFLAMMATION; IMMUNOGLOBULIN E
- Publication
Allergy, 2022, Vol 77, Issue 4, p1297
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15198