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- Title
Characterization of conjunctival microbiome dysbiosis associated with allergic conjunctivitis.
- Authors
Liang, Qiaoxing; Li, Jing; Zhang, Shiyao; Liao, Yinglin; Guo, Shixin; Liang, Juanran; Deng, Xiuli; Liu, Yu; Zou, Bin; Wen, Xiaofeng; Liang, Lingyi; Wei, Lai
- Abstract
Keywords: allergic conjunctivitis; microbiome; ocular surface EN allergic conjunctivitis microbiome ocular surface 596 600 5 02/20/21 20210201 NES 210201 Allergic conjunctivitis (AC) is one of the most common ocular surface diseases that encompasses a spectrum of diseases featured by antigen-specific immunoglobulin E (IgE) and T helper type 2 (Th2) lymphocyte-mediated hypersensitivity responses.1 Among different types of AC, seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) manifest the classical type I hypersensitivity. I Malassezia i produces immunogenic proteins that elicit IgE and thus induce pro-inflammatory cytokines and auto-reactive T cells, which contributes to atopic dermatitis pathogenesis.3 Notably, SAC/PAC is dominated by IgE-mediated reactions in contrast to VKC. A, Genus compositions of healthy subjects (n = 48) and AC patients with SAC/PAC (n = 21) or VKC (n = 18).
- Subjects
ALLERGIC conjunctivitis; IMMUNOGLOBULIN E; GRAFT versus host disease; FOOD allergy; ATOPIC dermatitis; MORAXELLA catarrhalis; RHINOVIRUSES; DERMATOPHAGOIDES pteronyssinus
- Publication
Allergy, 2021, Vol 76, Issue 2, p596
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14635