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- Title
Periodontal Disease and Biomarkers Related to Cardiovascular Disease.
- Authors
Joshipura, K. J.; Wand, H. C.; Merchant, A. T.; Rimm, E. B.
- Abstract
Periodontal disease is a chronic infection of the gums characterized by a loss of attachment between the tooth and bone, and by bone loss. We evaluated cross-sectionally the association between periodontal disease and C-reactive protein (CRP), fibrinogen, factor VII, tissue plasminogen activator (t-PA), LDL-C, von Willebrand factor, and soluble tumor necrosis factor receptors 1 and 2. The final sample consisted of 468 men (ages 47-80 yrs), participating in the Health Professional Follow-up Study, who provided blood and were free of CVD, diabetes, and cancer. In multivariate regression models controlling for age, cigarette smoking, alcohol intake, physical activity, and aspirin intake, self-reported periodontal disease was associated with significantly higher levels of CRP (30% higher among periodontal cases compared with non-cases), t-PA (11% higher), and LDL-C (11% higher). Based on our data, periodontal disease showed significant associations with biomarkers of endothelial dysfunction and dyslipidemia, which may potentially mediate the association between periodontal and cardiovascular disease.
- Subjects
PERIODONTAL disease; CARDIOVASCULAR diseases; TOOTH loss; BIOMARKERS; STOMATITIS; GINGIVAL diseases; C-reactive protein
- Publication
Journal of Dental Research, 2004, Vol 83, Issue 2, p151
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/154405910408300213