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- Title
Effects of low-dose alfentanil administration on central respiratory drive and respiratory pattern in spontaneously breathing ASA 1 patients.
- Authors
Conti, G.; Pierdominici, S.; Ferro, G.; Bocci, M.G.; Antonelli, M.; Proietti, R.
- Abstract
The aim of this study was to assess the short-term effects of the administration of low doses of alfentanil on respiratory drive and respiratory pattern. We studied 17 ASA I patients scheduled for minor surgery or endoscopic procedures. During spontaneous ventilation, Respiratory Rate, Tidal Volume, Total Respiratory Cycle, Inspiratory and Expiratory Time, Mean Inspiratory Flow, P0.1, S[sub a]o[sub 2] and Etco[sub 2] were all measured. The inspired oxygen concentration was 21% and measurements were made at baseline, 5 min (T1), 10 min (T2) and 15 min (T3) following an intravenous bolus injection 10 µg.kg[sup -1] alfentanil. The administration of alfentanil produced a significant (p < 0.05) reduction in S[sub a]o[sub 2], minute volume and P0.1. In ASA I spontaneously breathing patients, the pre-operative administration of low doses of alfentanil can initially reduce the respiratory centre activity leading to a reduction in minute volume and S[sub a]o[sub 2]. We therefore recommend careful monitoring of cardio-respiratory function in ASA I patients, following the administration of alfentanil.
- Subjects
ALFENTANIL; RESPIRATION; DOSE-response relationship in biochemistry; ANESTHETICS
- Publication
Anaesthesia, 2002, Vol 57, Issue 6, p540
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1046/j.1365-2044.2002.02573.x