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- Title
PI-42.
- Authors
Garcia-Bournissen, F.; Rokach, B.; Koren, G.
- Abstract
Background: Methamphetamine abuse has been gathering momentum as a serious public health problem. Evidence of chronic use, particularly during pregnancy, is hard to obtain.Methamphetamine accumulates in hair and can be detected several months after exposure. Drugs that cross the placenta can be detected in hair of newborns.Methods: We developed a hair immunoassay for methamphetamine at Motherisk laboratory in Toronto. The aim of the study was to find evidence of methamphetamine exposure during pregnancy using hair measurements of the drug.Results: Out of 1124 positive methamphetamine results, we identified 8 mother-child pairs who had methamphetamine positive hair. None of the pairs identified included mothers with negative results, but there were 2 (25%) of the neonates who had a negative methamphetamine result although the mother was positive. Mean methamphetamine values were 1.8 ng/mg of hair in the mothers and 1.08 ng/mg in the neonates. There was a trend towards correlation between maternal and fetal levels.Conclusion: To our knowledge, this is the first report that shows transplacental passage of methamphetamine, with accumulation in the fetal hair. We believe this provides the basis for studies to define pharmacokinetics of this drug in the mother-child couple.We have also shown that hair measurement of methamphetamine in neonates is a useful screening method to detect intra-uterus exposure. As fetal hair grows in the last trimester of pregnancy, a positive result may indicate maternal addiction.Clinical Pharmacology & Therapeutics (2005) 79, P18–P18; doi: 10.1016/j.clpt.2005.12.063
- Subjects
METHAMPHETAMINE abuse; NEWBORN infant health; DRUG abuse; MATERNAL health; PARENT-child relationships; PHARMACOKINETICS; MOTHER-infant relationship; PREGNANCY; MEDICAL care; HEALTH
- Publication
Clinical Pharmacology & Therapeutics, 2006, Vol 79, Issue 2, pP18
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1016/j.clpt.2005.12.063