We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
269: Tamsulosin facilitates clearance of stone fragments after Shockwave Lithotripsy for ureteric calculi: Results from an open-label randomized study.
- Authors
V., Naja; M. M., Agarwal; A. K., Mandal; S. K., Singh; U. K., Mete; S., Kumar; N., Acharya; N., Gupta
- Abstract
Introduction: To evaluate the role of tamsulosin in clearance of fragments after shock wave lithotripsy (SWL) to ureteric calculi. Methods: A prospective, randomized, open-label study was conducted during 2006-2007 enrolling 40 patients with single ureteric stone undergoing SWL. They were randomly divided based on whether or not receiving 0.4mg tamsulosin (group-A & B, respectively) during treatment and underwent evaluation & SWL 3-weekly till success or maximum of 3months. Clearance-rate, clearance-time, sessions required for clearance, pain-intensity, incidence of steinstrasse and need for auxiliary procedures were assessed. Results: Demographic profile of both the groups was comparable. Success-rate was higher in group-A after one SWL-session (55% vs. 25%, respectively; P=0.05). However, overall success rate was similar at 3 months (95% each group; P=1.00). Total number of days (30.68±19.65 vs. 37.89±19.89; P=0.269), number of SWL sessions (1.65 vs. 2.00; P=0.10) and pain experienced (score on visual analog scale- 25.27±17.86 vs. 38.33±28.02, respectively; P=0.10) tended to be less (though statistically insignificant) in group-A. Three patients in group-A and 5 in group B developed steinstrasse (15% vs. 25%; P=0.69); conservative management was successful in 2 of group-A & 3 of B (67% vs. 60%; P=1.00). Overall one in group-A required auxiliary procedures as compared to 4 in control group (5.0% vs. 20.0%, respectively; P=0.37). Conclusions: Tamsulosin facilitates clearance of stone fragments after SWL to ureteric calculi. It tends to reduce pain experienced during clearance and auxiliary procedures required for complication/clearance; however it requires further evaluation.
- Subjects
INDIA; PHARMACODYNAMICS; URINARY calculi; LITHOTRIPSY; PAIN management; RANDOMIZED controlled trials
- Publication
Indian Journal of Urology, 2008, Vol 24, pS138
- ISSN
0970-1591
- Publication type
Article