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- Title
170: Gene Polymorphisms of Interleukins in Benign Prostatic Hyperplasia.
- Authors
Singh, Vishwajeet; Rituraj, Konwar; Kumar, Bid Hemant; Sinha, Rahul Janak
- Abstract
Introduction: The cellular and genetic processes involved in the development and pathogenesis of BPH are not well understood and the cytokine pathways are known to be associated as major modifier therein. Though there are considerable evidences in vitro for BPH as a cytokine mediated disease, association of cytokine gene polymorphism has been not well established. Hypothesis: The potential associations between polymorphism in genes encoding IL-4 and IL-1 Ra cytokines and susceptibility of BPH in North Indian population. Methods: We analyzed the polymorphism of IL-1 Ra and IL-4 in fifty BPH patients and forty normal healthy controls. The polymorphisms were identified by variable number of tandem repeat (VNTR) analysis using PCR. Genotype distribution and allelic frequencies between patients and controls were compared. Mean as well as odds ratio (ORs) with 95% confidence intervals (CI) were calculated using SPSS software (version-11.5). Results: Genotype frequency distribution for IL-1 Ra polymorphisms between BPH and control group was statistically significant (P<0.001). However, no association was observed for IL-4 variants (P = 0.483). Conclusions: IL-1 Ra intron-3 polymorphism in our study appears to be plausible in determining the susceptibility and risk of BPH. Further studies will be needed to elucidate the net impact of IL- 1 Ra polymorphism on BPH and its role in disease pathogenesis.
- Subjects
INDIA; GENETIC polymorphisms; INTERLEUKINS; BENIGN prostatic hyperplasia; CYTOKINES; HEALTH risk assessment
- Publication
Indian Journal of Urology, 2008, Vol 24, pS111
- ISSN
0970-1591
- Publication type
Article