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- Title
Sclerosing Mucoepidermoid Carcinoma in the Parotid Gland With CRTC1-MAML2 Fusion: A Case Report.
- Authors
Yabuki, Kei; Matsuyama, Atsuji; Shiba, Eisuke; Nagatani, Gunji; Hisaoka, Masanori
- Abstract
In this article, we report a case of sclerosing mucoepidermoid carcinoma (MEC) arising in the parotid gland, with CRTC1-MAML2 gene fusion. A 73-year-old woman with a mass in the right parotid region was referred to our hospital. Radiological imaging tests revealed a well-defined mass, measuring 25 mm in diameter, with foci of calcification in the deep lobe of the parotid gland, extending to the parapharyngeal space. Microscopically, the tumor was composed of a proliferation of atypical glandular epithelial cells having intracytoplasmic mucin, squamoid cells and intermediate cells arranged in nests embedded in a fibrosclerotic stroma, associated with a dense chronic inflammatory infiltrate containing immunoglobulin G4-immunoreactive plasma cells. Reverse transcription-polymerase chain reaction analysis using a formalin-fixed, paraffin-embedded tumor tissue specimen revealed the CRTC1-MAML2 fusion gene transcript. This is the first report of sclerosing MEC with the detection of the MEC-associated fusion gene, reinforcing a common genetic association between MEC and sclerosing MEC.
- Subjects
DERMATOFIBROMA; PAROTID gland tumors; GENE fusion; CANCER cell proliferation; MUCINS; EOSINOPHILIA
- Publication
International Journal of Surgical Pathology, 2018, Vol 26, Issue 3, p250
- ISSN
1066-8969
- Publication type
Case Study
- DOI
10.1177/1066896917742721