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- Title
Proof of concept of triple COMBI therapy to prohibit MPN progression to AML.
- Authors
Hasselbalch, Hans Carl; Skov, Vibe; Kjær, Lasse; Larsen, Morten Kranker
- Abstract
Patients with accelerated or blast phase myeloproliferative neoplasms have a dismal prognosis. The report by de Castro et al. provides important information on the rationale and prospect for a novel therapeutic approach combining interferon‐alpha2 with 5‐azacytidine and a JAK1‐2 inhibitor (ruxolitinib) to be explored in well‐designed clinical trials. Commentary on: Castro et al. Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia. Br J Haematol 2024;204:206–220.
- Subjects
MYELOPROLIFERATIVE neoplasms; ACUTE myeloid leukemia; PROOF of concept; AZACITIDINE; RUXOLITINIB
- Publication
British Journal of Haematology, 2024, Vol 204, Issue 1, p16
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19173