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- Title
Spatial regulation and generation of diversity in signaling pathways.
- Authors
Saini, Neetu; Sarin, Apurva
- Abstract
Signaling pathways orchestrate diverse cellular outcomes in the same tissue, spatially and temporally. These interactions, which are played out in micro-environments within cells and involve a relatively small number of core pathways, are the key to the development and function of multi-cellular organisms. How these outcomes are regulated has prompted interest in intracellular mechanisms that build diversity in signaling outcomes. This review specifically addresses spatial positioning of molecules as a means of enabling interactions and novel outcomes of signaling cascades. Using the Notch and Ras pathways as exemplars, we describe mechanisms that contribute to diverse signaling outcomes.
- Subjects
MULTICELLULAR organisms
- Publication
Journal of Biosciences, 2021, Vol 46, Issue 1, p1
- ISSN
0250-5991
- Publication type
Article
- DOI
10.1007/s12038-021-00150-w