We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats.
- Authors
Woosuk Kim; Dae Won Kim; Dae Young Yoo; Hyo Young Jung; Jong Whi Kim; Dong-Woo Kim; Jung Hoon Choi; Seung Myung Moon; Yeo Sung Yoon; In Koo Hwang
- Abstract
Background: Dendropanax morbifera Léveille has been employed for the treatment of infectious diseases using folk medicine. In this study, we evaluated the antioxidant effects of a leaf extract of Dendropanax morbifera Léveille in the hippocampus of mercury-exposed rats. Methods: Seven-week-old Sprague-Dawley rats received a daily intraperitoneal injection of 5 ##181;g/kg dimethylmercury and/or oral Dendropanax morbifera Léveille leaf extract (100 mg/kg) for 4 weeks. Animals were sacrificed 2 h after the last dimethylmercury and/or leaf extract treatment. Mercury levels were measured in homogenates of hippocampal tissue, a brain region that is vulnerable to mercury toxicity. In addition, we measured reactive oxygen species production, lipid peroxidation levels, and antioxidant levels in these hippocampal homogenates. Results: Treatment with Dendropanax morbifera Léveille leaf extract significantly reduced mercury levels in hippocampal homogenates and attenuated the dimethyl mercury-induced increase in the production of reactive oxygen species and formation of malondialdehyde. In addition, this leaf extract treatment significantly reversed the dimethylmercury-induced reduction in the hippocampal activities of Cu, Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase. Conclusion: These results suggest that a leaf extract of Dendropanax morbifera Léveille had strong antioxidant effects in the hippocampus of mercury-exposed rats.
- Subjects
REACTIVE oxygen species; ANIMAL experimentation; ANTIOXIDANTS; BRAIN injuries; GLUTATHIONE; HIPPOCAMPUS (Brain); LEAVES; LIPID peroxidation (Biology); MERCURY; RATS; RESEARCH funding; SUPEROXIDE dismutase; PLANT extracts; DATA analysis software; DESCRIPTIVE statistics
- Publication
BMC Complementary & Alternative Medicine, 2015, Vol 15, Issue 1, p1
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/s12906-015-0786-1