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- Title
Meta-analysis of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma.
- Authors
Yueshu Wang; Wei Ding; Chuang Chen; Zhihao Niu; Ming Pan; Hong Zhang; Wang, Yueshu; Ding, Wei; Chen, Chuang; Niu, Zhihao; Pan, Ming; Zhang, Hong
- Abstract
<bold>Background: </bold>With radiotherapy (RT) alone, the five-year overall survival (OS) rate for advanced nasopharyngeal carcinoma (NPC) can only reach 40%, the ratio of distant metastasis (DM) is 36-40%. This meta-analysis was performed to compare the clinical efficacy of concurrent chemoradiotherapy (CCRT) with RT alone in the treatment of locoregionally advanced NPC.<bold>Methods: </bold>The related literature were retrieved and reviewed by two independent investigators from the followed electronic databases: Review manager 5.3 software (Cochrane Collaboration, London, United Kingdom) was applied for statistical analysis.<bold>Results: </bold>A total of 16 trials with 2576 patients were recruited according to the criterion. The odds ratios of 3 and 5 years OS was 0.53 (95% confidence interval [95% CI]: 0.44-0.64) and 0.58 (95% CI: 0.48-0.71), which confirmed the significant improvement of CCRT compared with RT alone (P < 0.001). CCRT also reduced the risk of locoregional control failure and DM in locoregionally advanced NPC patients.<bold>Conclusions: </bold>The results suggested that CCRT was more beneficial when compared with RT alone in locoregionally advanced NPC patients. Further study is needed to perform to confirm this effect.
- Subjects
COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; META-analysis; METASTASIS; NASOPHARYNX tumors; RESEARCH; TUMOR classification; EVALUATION research; TREATMENT effectiveness; ODDS ratio; TUMOR treatment
- Publication
Journal of Cancer Research & Therapeutics, 2015, Vol 11, pC191
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.168183