We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia as progression of myeloid neoplasm with platelet-derived growth factor ß rearrangement.
- Authors
Xue Shi; Zhan Su; Chunting Zhao; Xianqi Feng; Shi, Xue; Su, Zhan; Zhao, Chunting; Feng, Xianqi
- Abstract
Myeloid neoplasms associated with platelet-derived growth factor b (PDGFRB) rearrangement usually keep only one morphologic type unless blast crisis. We describe a unique case of hematological features transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia, and imatinib showed no clinical therapeutic effects. The phenomenon indicates that different types of myeloid neoplasms associated with PDGFRB rearrangement can transform into one another with the progression of the disease, and to some extent, this transformation suggests the aggravation of disease.
- Subjects
GENETIC transformation; PLATELET-derived growth factor; HEMATOLOGY; DRUG therapy; IMATINIB; DISEASE progression
- Publication
Journal of Cancer Research & Therapeutics, 2015, Vol 11, Issue 4, p914
- ISSN
0973-1482
- Publication type
case study
- DOI
10.4103/0973-1482.160922