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- Title
Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial.
- Authors
Giannini, I.; Amato, A.; Basso, L.; Tricomi, N.; Marranci, M.; Pecorella, G.; Tafuri, S.; Pennisi, D.; Altomare, D.
- Abstract
Background: The role of a mixture of phlebotonics in the treatment of acute hemorrhoid crisis is investigated to test their efficacy. Methods: One hundred and thirty-four consecutive patients with an acute hemorrhoidal crisis recruited in five colorectal units entered the study. Sixty-six of them were randomized to receive a mixture of diosmin, troxerutin and hesperidin (group A), and 68 a placebo (group B). The main symptoms, the use of oral painkillers and the Bristol scale score were recorded at each scheduled visit and compared using both Student's t test for independent samples and the ANOVA models for repeated measures. The presence of edema, prolapse and thrombosis were also recorded and compared using the Chi-square test. Furthermore, the trend of proportions during the time of the evaluations was assessed by the Chi-square test for linear trend. Results: Pain, bleeding and the proportion of patients who reported persistence of edema and thrombosis decreased significantly after 12 days of treatment in group A. After 6 days, the number of paracetamol tablets taken by patients in group A was significantly lower than the amount of flavonoid mixture. Conclusions: The use of a mixture of diosmin, troxerutin and hesperidin is a safe and effective mean of managing symptoms of acute hemorrhoidal disease. Furthermore, in patients receiving treatment, there was faster control and lower persistence of edema and thrombosis.
- Subjects
FLAVONOIDS; TREATMENT of hemorrhoids; DIOSMIN; HESPERIDIN; THROMBOSIS; EDEMA; CLINICAL trials
- Publication
Techniques in Coloproctology, 2015, Vol 19, Issue 6, p339
- ISSN
1123-6337
- Publication type
Article
- DOI
10.1007/s10151-015-1302-9