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- Title
Expanding Insight into Asymmetric Palladium-Catalyzed Allylic Alkylation of N-Heterocyclic Molecules and Cyclic Ketones.
- Authors
Bennett, Nathan B.; Duquette, Douglas C.; Kim, Jimin; Liu, Wen‐Bo; Marziale, Alexander N.; Behenna, Douglas C.; Virgil, Scott C.; Stoltz, Brian M.
- Abstract
Eeny, meeny, miny …︁ enaminones! Lactams and imides have been shown to consistently provide enantioselectivities substantially higher than other substrate classes previously investigated in the palladium‐catalyzed asymmetric decarboxylative allylic alkylation. Several new substrates have been designed to probe the contributions of electronic, steric, and stereoelectronic factors that distinguish the lactam/imide series as superior alkylation substrates (see scheme). These studies culminated in marked improvements on carbocyclic allylic alkylation substrates.
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 14, p4414
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201300030