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- Title
Heptamethine Cyanine‐Based Nanotheranostics with Catalase‐Like Activity for Synergistic Phototherapy of Cancer.
- Authors
Liang, Mingchen; Mu, Xueluer; Li, Yue; Tan, Yuanhang; Hao, Xiaoying; Tang, Ying; Wang, Zigeng; Feng, Wenbi; Lu, Yingxi; Zhou, Xianfeng
- Abstract
Single‐molecule photosensitizers (PSs) for synergistic phototherapy are desirable but highly challenging, due to the competitive relationship between photothermal (PTT) and photodynamic therapy (PDT). Herein, a supramolecular strategy is developed that can tune the stacking pattern of PS molecules in their aggregates to optimize the PTT/PDT efficiency. Specifically, near‐infrared (NIR) heptamethine cyanines (Cy7) are synthesized using tricyanofuran (TCF) as the acceptor and benzothiazole (BTH)/indole (IND) as the donor, where BTH is a less hydrogen‐bonded tecton relative to IND. Both IND‐Cy7‐TCF and BTH‐Cy7‐TCF have similar photophysical properties at the molecular level, but BTH‐Cy7‐TCF in aggregated state exhibits higher singlet oxygen quantum yield (1.3% vs 0.2%) and competitive photothermal conversion efficiency (56.4% vs 62.3%) compared to IND‐Cy7‐TCF, due to the fine‐tuning of hydrogen bonding and intermolecular π–π interactions to form loose molecular stacks. Interestingly, the unique molecular stacking structure provides a binding site and catalytic center for H2O2 that exhibits catalase‐like activity, which can further ameliorate the efficiency of PDT and enhance the synergistic effect of PDT/PTT phototherapy in vitro and in vivo. This study can provide a simple but effective supramolecular strategy to design small molecule PSs with desirable aggregated structure for synergistic dual‐mode phototherapy.
- Subjects
PHOTOTHERAPY; PHOTODYNAMIC therapy; PHOTOTHERMAL conversion; REACTIVE oxygen species; MOLECULAR structure; CYANINES
- Publication
Advanced Functional Materials, 2023, Vol 33, Issue 37, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202302112