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- Title
Right and left ventricular interactions, strain, and remodeling in repaired pulmonary stenosis patients with preserved right ventricular ejection fraction: A cardiac magnetic resonance study.
- Authors
Wang, Shi‐yu; OuYang, Rong‐zhen; Hu, Li‐wei; Xie, Wei‐hui; Peng, Ya‐feng; Wang, Lei; Gao, Fa‐bao; Zhong, Yu‐min; Wang, Shi-Yu; OuYang, Rong-Zhen; Hu, Li-Wei; Xie, Wei-Hui; Peng, Ya-Feng; Gao, Fa-Bao; Zhong, Yu-Min
- Abstract
<bold>Background: </bold>Right ventricular dilation and dysfunction is a common long-term complication in patients with repaired pulmonary stenosis (rPS). Additionally, abnormal right and left ventricular interactions have been reported in right-sided heart defect after intervention, including in pulmonary stenosis.<bold>Purpose: </bold>To analyze ventricular strain, remodeling, and left and right ventricular interactions in rPS patients with preserved right ventricular ejection fraction (RVEF) compared with healthy children using cardiac magnetic resonance.<bold>Study Type: </bold>A cross-sectional study.<bold>Population: </bold>In all, 34 rPS patients and 10 healthy children volunteers (controls).<bold>Field Strength/sequence: </bold>3.0T/2D balanced steady-state free precession (2D b-SSFP) cine, late gadolinium enhancement (LGE), and 2D phase contrast (2D-PC).<bold>Assessment: </bold>Pulmonary regurgitation (PR) fractions of the main pulmonary artery, biventricular volumes, masses, function, and cardiac strain.<bold>Statistical Tests: </bold>Mann-Whitney U-test, t-test, Pearson correlation coefficients, Spearman's correlation coefficients, and intraclass correlation coefficients analysis were performed.<bold>Results: </bold>For group analysis, the right ventricular (RV) global circumferential strain and radial strain were significantly increased in patients when compared with controls (-13.57 ± 2.69 vs. -5.91 ± 3.16, P < 0.001; 25.31 ± 8.12 vs. 9.87 ± 5.32, P < 0.001, respectively). The fraction of PR displayed moderate correlation with right ventricular end-diastolic volume index (RVEDVi) (r = 0.452, P = 0.022). RVEDVi and mass index were larger in patients vs. control (104.92 ± 27.46 vs. 85.15 ± 11.98, P = 0.016; 18.28 ± 4.95g/m2 vs. 11.67 ± 2.14 g/m2 , P < 0.001, respectively). Patients presented with preserved left ventricular ejection function, but was lower than healthy controls (60.89% ± 4.89% vs. 65.95% ± 4.56%, P = 0.006). Regional circumferential strain of segment 3 of left ventricle (LV) were significantly decreased in patients (-7.79 ± 6.52 vs. -13.56 ± 3.22, P = 0.003).<bold>Data Conclusion: </bold>Compensated increased RV strain, myocardial remodeling of RV, and adverse right and left ventricular interactions occur in rPS patients with preserved RVEF. The decreased interventricular septum strain may lead to impaired LV function due to RV dilation as a result of PR.<bold>Level Of Evidence: </bold>3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;52:129-138.
- Subjects
VENTRICULAR ejection fraction; PATIENTS' rights; PULMONARY stenosis; MAGNETIC resonance; INTRACLASS correlation; RESEARCH; TETRALOGY of Fallot; CROSS-sectional method; RIGHT heart ventricle; RESEARCH methodology; CONTRAST media; NUCLEAR magnetic resonance spectroscopy; MAGNETIC resonance imaging; MEDICAL cooperation; EVALUATION research; HEART ventricles; CHEMICAL elements; COMPARATIVE studies; RIGHT ventricular dysfunction; RESEARCH funding; STROKE volume (Cardiac output); HEART physiology
- Publication
Journal of Magnetic Resonance Imaging, 2020, Vol 52, Issue 1, p129
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.27034