We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antimicrobial and Cytotoxic Secondary Metabolites from a Marine-Derived Fungus Penicillium Citrinum VM6.
- Authors
Anh, Nguyen Mai; Huyen, Vu Thi Thu; Quyen, Vu Thi; Dao, Phi Thi; Quynh, Do Thi; Huong, Doan Thi Mai; Van Cuong, Pham; Dat, Ton That Huu; Minh, Le Thi Hong
- Abstract
Investigation of an antimicrobial and cytotoxic ethyl acetate extract prepared from solid fermentation of the marine-derived fungus Penicillium citrinum VM6 led to the isolation of eight metabolites (1–8), including one citrinin dimer dicitrinone F (1). Of these, compound 7 was isolated for the first time from the Penicillium genus and compound 1 with carbon-bridged C-7/C-7’ linkage is rarely reported. All compounds (1–8) exhibited selective antimicrobial activity against the tested Gram-positive bacteria and Candida albicans with MICs of 32–256 µg/mL. Compounds 1 and 8 exhibited cytotoxicity against all tested cell lines A549, MCF7, MDA-MB-231, Hela, and AGS with IC50 values of 6.7 ± 0.2 to 29.6 ± 2.2 µg/mL, whereas compound 5 had selective cytotoxicity against the MCF7 cell lines with IC50 of 98.1 ± 7.8 µg/mL.
- Publication
Current Microbiology, 2024, Vol 81, Issue 1, p1
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-023-03568-7