We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Caution: Chemical Instability of Natural Biomolecules During Routine Analysis.
- Authors
Pannequin, Anaïs; Laurini, Erik; Giordano, Laurent; Muselli, Alain; Pricl, Sabrina; Tintaru, Aura
- Abstract
Natural products (NPs) constitute a significant source of active biomolecules widely used in medicine, pharmacology and cosmetics. However, NPs structural characterization has the drawback of their chemical instability during the extraction steps and their likely transformation during the analytical protocol. In particular, tamariscol and conocephalenol are two compounds largely used in the cosmetic industry for their odorant properties. Thus, in the present study, we focused on the evolution of these two metabolites (extracted from Frullania tamarisci and Conocephalum conicum, respectively), as followed by NMR. Interestingly, we found that, once dissolved in deuterated chloroform, these two tertiary alcohols are both subjected to transformation processes, leading to degradation compounds with altered structures. Accordingly, these detected degradation compounds have been fully characterized by NMR and the experimental findings were supported by computational chemistry data.
- Subjects
BIOMOLECULES; CHLOROFORM; COMPUTATIONAL chemistry; COSMETICS industry; NATURAL products; LEAD compounds
- Publication
Molecules, 2020, Vol 25, Issue 14, p3292
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25143292