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- Title
Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent.
- Authors
Hanh, Bui Thi Bich; Park, June-Woo; Kim, Tae Ho; Kim, Jae-Sung; Yang, Chul-Su; Jang, Kiseok; Cui, Jinsheng; Oh, Dong-Chan; Jang, Jichan
- Abstract
Mycobacterium abscessus is the most difficult-to-treat nontuberculous mycobacteria because of its resistance to many antibiotics. In this study, we screened the Korea Chemical Bank library for a bioluminescent reporter assay to identify molecules capable of acting against M. abscessus. On application of the assay, rifamycin O showed excellent in vitro activity with a narrow range of the minimum inhibitory concentration required to inhibit the growth of 90% of the bacterium (MIC90 = 4.0–6.2 μM); its in vivo efficacy in the zebrafish (Danio rerio) infection model was comparable to that of rifabutin at 25 μM. Furthermore, rifamycin O did not show significant toxicity in cells and the zebrafish model. These results are the first in vivo indication that rifamycin O may be a drug candidate for treating M. abscessus infections.
- Subjects
RIFAMYCINS; ZEBRA danio; DRUG resistance in bacteria; BIOLUMINESCENCE assay; CHEMICAL libraries
- Publication
Molecules, 2020, Vol 25, Issue 7, p1597
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25071597