We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hydrophobically Modified Glucan as an Amphiphilic Carbohydrate Polymer for Micellar Delivery of Myricetin.
- Authors
Yang, Weiyu; Guo, Ling; Li, Fenfen; Liu, Xin; Nie, Shaoping; Xie, Mingyong; Huang, Danfei; Xiao, Jianbo; Zhang, Yanbo; Ni, Hui
- Abstract
Myricetin (Myr) is a phytochemical with many functional properties. However, its hydrophobicity, low bioavailability, and stability limit its application. In this study, octadecanoate oat β-glucan (OGE) was synthesized and gained recognition as a self-assembled micelle forming a polymer with a critical micelle concentration (CMC) of 59.4 μg/mL. The Myr-loaded OGE micelle was then prepared and characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), X-ray diffractometer (XRD), and Fourier-transform infrared spectroscopy (FT-IR) spectra. The water solubility of Myr was greatly enhanced by forming the Myr/OGE inclusion complex. Consequently, compared to free Myr, the retention of Myr in Myr-loaded OGE micelle was effectively increased during the intestinal digestion phase, and its antioxidant activity was also improved. Overall, our findings demonstrated the potential applications of OGE polymer for the development of prospective micelle in health food, cosmetics, and pharmaceutical fields because they can aid in the delivery of hydrophobic functional compounds like Myr.
- Subjects
MYRICETIN; CRITICAL micelle concentration; POLYMERS; GLUCANS; TRANSMISSION electron microscopes; HYDROPHOBIC compounds
- Publication
Molecules, 2019, Vol 24, Issue 20, p3747
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24203747