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- Title
Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu).
- Authors
Nam, Bomi; Ryu, Seung Mok; Lee, Dongho; Jung, Chan-Hun; Jin, Chang Hyun; Kim, Jin-Baek; Lee, Ik-Soo; Han, Ah-Reum
- Abstract
Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3–9), two bibenzyls (10–12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3–6, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 μM.
- Subjects
SQUAMOUS cell carcinoma; HYPOPHARYNX; NEOLIGNANS; MASS spectrometry; CIRCULAR dichroism
- Publication
Molecules, 2019, Vol 24, Issue 12, p2339
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24122339