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- Title
Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis.
- Authors
Xiang-Yu Li; Yang Yu; Miao Jia; Mei-Na Jin; Nan Qin; Chuan Zhao; Hong-Quan Duan
- Abstract
Nine new pregnane alkaloids (1–9), together with eight known alkaloids (10–17),were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002.
- Publication
Molecules, 2016, Vol 21, Issue 10, p1283
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21101283